ERBB2 and breast carcinoma: Consistent with our previously-published results in prostate and bladder cancer cell lines [15,16,17,18], we also have shown that FKA exhibited a robust mechanism of inducing apoptosis in HER2-overexpressing breast cancer cell lines by increasing the expression of proapoptotic proteins Bim and BAX and decreasing anti-apoptotic proteins (i.e., Bcl-2, Bcl-X/L, XIAP, and survivin).