BCL2 and neoplasm: Overexpression of HER2 commonly causes the resistance of apoptosis by increasing anti-apoptotic proteins (e.g., Bcl-2, Bcl-X/L, Mcl-1, and survivin) and decreasing the proapoptotic protein Bim and, thus, contributes to tumor progression and contributes to the resistance to chemotherapy [9,28,29,30,31].