Previously, we established a bacterial expression system to produce lectin PPA genetically fused with soluble coxsackie-adenovirus receptor (sCAR) [27,28], which successfully re-direct adenovirus to preferentially infect drug resistant leukemic K562/ADR cells and lung cancer H460/5Fu cells [29], suggesting that sCAR-lectin combined with adenoviruses could be developed to form therapeutic vectors to deliver anticancer genes into cancer cells. This evidence concerns the gene RPS4X and lung cancer.