VIM and hepatocellular carcinoma: In the present study, asialoglycoprotein receptors (ASGPR) targeting-ligand-based liposomes were prepared by cationic lipid (DMKE), POPC, cholesterol, PEG2000-DSPE, and galactosylated ceramide to co-deliver DOX and vimentin siRNA, expecting to target hepatic carcinoma sites, enhance transfection efficiency, and realize the optimal combination therapy (as shown in Scheme 1).