In contrast, the patient that we describe in this report with the c.215A > G missense CISD2 variant had the classical features of Wolfram syndrome type 1, namely early-onset diabetes mellitus and progressive optic atrophy, but at the age of 45 years old, he had not been diagnosed with peptic ulcer disease or significant haematological abnormalities. This evidence concerns the gene CISD2 and peptic ulcer disease.