TF and autoimmune disease: VDR binding peaks were significantly concentrated within proposed functional elements, specifically regions of high regulatory factor binding (HOT regions (17) and clustered TF binding sites from ENCODE), active promoters, enhancers and insulators (Fig. 1E;, Supplementary Material, Fig. S7) and previously reported GWAS disease loci, principally for autoimmune disorders (Supplementary Material, Fig. S8).