From this, we report a significant excess of VDR-rBVs coincident or in strong LD with genome-wide significant GWAS tag variants for six disorders, including three that are autoimmune disorders (inflammatory bowel disease, Crohn’s disease and rheumatoid arthritis) whilst a fourth, endometriosis, is frequently comorbid with autoimmune disorders (50). This evidence concerns the gene VDR and Crohn disease.