TUBB3 and tubulinopathy: Notably, mutations in tubulin genes encoding different α- and β-tubulin isotypes (TUBA1A, TUBA8 and TUBB2B, TUBB3, TUBB5 and TUBG1), have previously been shown to be involved in a large spectrum of developmental brain disorders collectively referred to as tubulinopathies (Keays et al., 2007; Abdollahi et al., 2009; Jaglin et al., 2009; Tischfield et al., 2010; Breuss et al., 2012; Poirier et al., 2013; Bahi-Buisson et al., 2014), further highlighting the critical role of the microtubule cytoskeleton in normal human nervous system development (Jaglin and Chelly, 2009; Tian et al., 2010).