MAPT and early-onset autosomal dominant Alzheimer disease: Together, these studies suggest that p.A152T is a risk factor for diverse neurodegenerative disease syndromes related to FTLD-tau and possibly synucleinopathy, although recently, a study of 11 572 subjects in Spain did not observe an increased association between p.A152T and Alzheimer’s disease, while the association with FTD spectrum approached significance [odds ratio (OR) = 2.03; P = 0.063] (Pastor et al., 2016).