MPS1 is overexpressed in various human tumours, including breast, pancreatic, thyroid and glioblastoma, and its higher expression levels correlate with poor prognosis in many of these tumours (Salvatore et al, 2007; Daniel et al, 2011; Tannous et al, 2013; Slee et al, 2014). This evidence concerns the gene TTK and neoplasm.