In addition, in a panel of 20 breast cancer cell lines, we found that the basal, as well as specifically the PTEN-deficient basal cancer cells, were more sensitive to cell death by CCT271850 in comparison to luminal breast cancer cell lines (average IC50 at 96 h: Basal=0.7±0.2, Luminal=2.1±0.54; P=0.014; Table 2). Here, PTEN is linked to breast cancer.