SLC47A1 and cerebral toxoplasmosis: Pyrimethamine may depress folate metabolism in patients taking agents associated with myelosuppression, such as zidovudine.[46] Pyrimethamine did not affect zidovudine exposure at doses used to treat cerebral toxoplasmosis.[66] Potentially, pyrimethamine may reduce the renal clearance of emtricitabine and lamivudine, as in vitro data suggest that pyrimethamine inhibits renal transport via the multidrug and toxin extrusion transporter MATE1.[67, 68]