Variables showing hazardous effects for HCC survival were bilirubin (HR 1.11; 95% CI 1.09–1.12; p<0.001), INR (HR 3.13; 95% CI 2.46–3.97; p< 0.001), serum AFP (HR 1.01; 95% CI 1.01–1.01 p< 0.001), total tumor volume (HR per 1,000ml increment 1.33; 95% CI 1.26–1.40; p< 0.001), variceal bleeding (HR 1.38; 95% CI 1.04–1.83; p = 0.024), vascular invasion (HR 2.59; 95% CI 2.24–3.00; p< 0.001), ascites (HR 2.26; 95% CI 1.95–2.61; p< 0.001), and platelet count (HR per 10,000/m3 increment: 1.02; 95% CI 1.02–1.03; p< 0.001). Here, AFP is linked to hepatocellular carcinoma.