TP63 and split hand-foot malformation 4: In humans, mutations in the p63 gene cause several kinds of diseases with limb deformities, including split-hand/split-foot malformation 4 (SHFM4), ectrodactyly and ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3), and ankyloblepharon-ectodermal defects-clefting (AEC) syndrome [19].