As HBV alters the methylation and interacts with TP53 in HCC, we next analyzed the methylation of FBLN1 and VIM in six liver cell lines (HepaRG, HepG2, HepG2/2.2.15, Hep3B, Mahlavu and PCL/PRF/5) with different TP53 mutation and HBV-status. Here, FBLN1 is linked to hepatocellular carcinoma.