Similarly, the co-labeling with a pan-endothelial determinant PECAM-1 was significantly reduced after MI in the cohorts of podoplanin-presenting cells (S3 Fig Panel B, PECAM-1), further demonstrating that a large share of podoplanin-bearing cells appearing after infarction in the myocardial interstitium did not display markers of mature endothelium. Here, PDPN is linked to infarction.