ITGB3 and chronic hepatitis C virus infection: We devised strategies utilizing the infectious JFH1 cell culture system10, 11, 12, screened for small molecule inhibitors with novel MOAs, and identified IDPP as a potential drug candidate for chronic hepatitis C. IDPP showed very potent antiviral activity (EC50 46 ± 26 pM) against HCV gt2 (Fig. 1) without causing cytotoxicity (CC50 30 μM, S2 Fig).