TP53 and renal cell carcinoma: Elevation of miR-185, which is downregulated in response to IR sensitizes renal cell carcinoma cells to IR both in vitro and in vivo by targeting ATR kinase.16 The p53-responsive miRNA miR-34a binds to the 3′UTR of RAD51 and inhibits double-strand break repair in NSCLC cells.14