As the delay in MDA-231 tumor onset could also have been due to increased apoptosis in Kaiso-depleted cells, we investigated the effect of Kaiso depletion on the expression of the apoptotic/cell-death marker–cleaved Caspase 3 (c-Caspase 3) in MDA-231 tumor tissues. The gene discussed is ZBTB33; the disease is neoplasm.