STAT3 and cancer: Recent evidence indicated that miR-665 was upregulated in intestinal gastric adenocarcinoma.24 It is reported that IBD has the risk of developing colitis associated cancer (CAC), and the increasing cancer incidence has been up to 20%.25 Polytarchou et al. 26 recently have found that miR-214 was overexpressed by IL-6/STAT3 signaling activation, and modulated the expressions of phosphatase and tensin homolog (PTEN), PDZ and LIM domain 2 (PDLIM2) and phosphorylation of AKT, which induced the activation of nuclear factor-κB (NF-κB).