Moreover, they demonstrated that the signaling correlates with the progression to colorectal cancer.26 Meanwhile, the NF-κB transcription factor family is an important initiator of inflammation by ER stress, leading to the production of proinflammatory TNF-α and exacerbating stress-induced cell death.27 Interestingly, our results indicated that ectopic expression of miR-665 promoted apoptosis under different inflammatory stimuli, such as TNF-α. This evidence concerns the gene TNF and colorectal cancer.