NFKB1 and diabetes mellitus: These results confirm that the type 2 diabetes with cardiomyopathy rat model was successfully established, which is consistently with previous studies.36, 37, 38 NOX2 upregulation, oxidative stress, NFκB activation and inflammation were found in the myocardium of DM rats, which were attenuated by silencing salusin-β gene in diabetic rats.