GAS6 and acute myeloid leukemia: Another study showed that following the stimulation of an AML cell line with Gas6, prosurvival and proliferative signalling pathways were activated, including the phosphorylation of ERK1/2, p38, mitogen- and stress-active protein kinase 1 (MSK1), cAMP-response element binding protein (CREB), ATF-1, Akt and STAT6.76 In conclusion, all these results indicate that the expression of Gas6/TAM promotes the development of acute leukaemia.