GAS6 and Familial prostate cancer: For example, stimulation of Gas6/Mer results in activation of the Janus tyrosine kinase (JAK)/STAT signalling pathway in melanoma.56 A microarray analysis demonstrated that Mer is a strong inducer of chemokines such as interleukin (IL)-8 in human prostate cancer cells.57 Wu et al.58 found that Mer activation, either with or without Gas6, induces Src-mediated tyrosine phosphorylation of focal adhesion kinase (FAK) and its recruitment to the integrin αβ5.