TYRO3 and leukemia: Tyro3 was first identified in 1993 and was primarily found in the central nervous system (CNS).59 Although information on the status of Tyro3 expression in human cancer is scant, Tyro3 has been detected in several human leukaemia cell lines and blasts of acute myeloid leukaemia patients60 and is overexpressed in myeloma cells compared with its expression in autologous B-lymphoblastoid cell lines.61 Tyro3, a receptor tyrosine kinase, transduces signals from the extracellular matrix into the cytoplasm by binding to Gas6.