Numerous researches considering shRNA knockdown of TAM receptors have been shown effective in inhibition of different kinds of tumours including breast carcinoma, melanoma, PDA, osteosarcoma, NSCLC, thyroid cancer and AML.6, 7, 15, 56, 64, 69, 102 In addition, selective small-molecule inhibitors of Axl and Mer have been generated. The gene discussed is AXL; the disease is osteosarcoma.