TYRO3 and cancer: Gas6 binds receptor tyrosine kinases (RTKs) of the TAM family, which comprises Tyro3, Axl and Mer, and then activates downstream signalling through which Gas6 exerts biological effects, including cell survival, migration and growth.11 Moreover, Gas6 has a critical role in the development of multiple types of cancers, including pancreatic, prostate, oral, ovarian and renal cancers.12, 13, 14, 15, 16 Clinically, the expression of Gas6 and TAM receptors always predicts poor prognosis.