However, several studies have indicated downstream signalling involved in the biological effects of Gas6/TAM.7, 31, 74, 76 Whitman et al.74 derived a Gas6-associated gene-expression signature in GAS6+ patients who included overexpression of BAALC and MN1 (known to confer an adverse prognosis in AML) as well as CXCL12 (encoding a stromal cell-derived factor) and its receptor genes, chemokine (C-X-C motif) receptor 4 (CXCR4) and CXCR7. The gene discussed is CXCR4; the disease is acute myeloid leukemia.