Application of BGB324 monotherapy inhibits the proliferation of FLT3-mutated MV4-11 cells.71 When two independent shRNA constructs were used to decrease Mer expression in the AML cell lines Nomo-1 and Kasumi-1,7 the reduction of Mer protein levels significantly increased the rate of myeloblast apoptosis by two- to three-fold in response to serum starvation. This evidence concerns the gene MERTK and acute myeloid leukemia.