Western blot analyses showed that Bcl-2 T69 phosphorylation was markedly decreased upon overexpression of NPAS2 or CDC25A in HCC cells, whereas the phosphorylation of Bcl-2 T69 was significantly enhanced in HLE cells with NPAS2 or CDC25A knockdown (Figure 7c). Here, CDC25A is linked to hepatocellular carcinoma.