This is of vital significance as G-MDSCs are able to induce unresponsiveness of T cells to specific antigens: peroxynitrite produced by G-MDSCs leads the nitration of T-cell receptors (TCRs), thereby blocking TCR/MHC-peptide specific recognition.35, 36 Thus, our study suggested that the recruitment of rapamycin-induced MDSCs, especially G-MDSCs was at least partially responsible for the amelioration of acute kidney injury. The gene discussed is HLA-C; the disease is acute kidney injury.