AKT1 and renal cell carcinoma: Noticeably, data analyses of reverse-phase protein array-based protein expression from 212 clinical RCC samples indicated that activated PDPK1 (S241) was positively correlated with PI3K, AKT, GSK3β, β-catenin, and mTOR/P70S6K1 and negative correlated with cell cycle and apoptotic proteins (Table 1).