Among the targets of oridonin, proteases, transcription factors, and kinases (e.g., telomerase, c-Myc, EGFR, p21, NF-κB, Ras, JNK, and p38) have been characterized.24, 25, 26, 27, 28 In RCC, we identify a novel target of CYD-6-17, PDPK1, and unveil that GSK3β/β-catenin is the key downstream effector of PDPK1 in mediating RCC growth. Here, PDPK1 is linked to renal cell carcinoma.