Additionally, forced expression of wild-type MYCN can promote SHH-independent medulloblastoma development when driven from the brain-specific Glutamate transporter 1 (Glt1) promoter in the Tet-inducible Glt1-tTA;TRE-MYCN/Luciferase (GTML) transgenic model [88]. This evidence concerns the gene SHH and medulloblastoma.