Pei et al. introduced a mutationally stabilized c-Myc (c-MycT58A) and dominant negative Trp53 (DNp53) in postnatal stem cells expressing Prominin-1 (CD133) but lacking expression of lineage-specific markers defining CGNPs [57].Using c-MycWT constructs also induced tumor formation in conjunction with DNp53, but with reduced penetrance and increased latency. The gene discussed is PROM1; the disease is neoplasm.