Screens including either grade II and grade III gliomas [43] or pediatric HGGs [35,36,37,46] have demonstrated amplifications of both c-MYC as well as MYCN, and in the context of pediatric HGG a clear association of MYCN amplifications with anaplastic astrocytomas was reported [46]. The gene discussed is MYC; the disease is anaplastic astrocytoma.