TRPA1 and skin disorder: Moreover, TRPV2 and TRPA1 seem to be involved in insulin secretion [20], TRPV1 and TRPV2 in heart hypertrophy [14,15], TRPV3 in skin disorders [14], TRPV1 and TRPA1 in airway irritation and cough [21], and TRPV1, TRPV2 and TRPA1 in cancer [22,23].