Junod et al. [33] found that, 24 hours after the intravenous administration of STZ in doses up to 40 mg/kg, Wistar rats develop symptoms of type 1 DM, such as hyperglycemia, glycosuria, and significant decreases in pancreatic and serum insulin; these metabolic derangements remained unchanged for long periods after STZ administration. This evidence concerns the gene INS and Hyperglycemia.