Taken together, our study indicates that Cxcr4b-mediated signalling is required to mediate the full angiogenesis response to mycobacterial infections, and that suppression of pathological angiogenesis with CXCR4 blockers might represent an alternative therapeutic strategy to suppress granuloma-angiogenesis without perturbing VEGF signalling. The gene discussed is VEGFA; the disease is Granuloma.