Based on the results from our allergy mouse model we anticipated that the acrolein-associated immune suppression could be detrimental in cancer, as it is generally accepted that in many cancer types like breast cancer51, hepatocellular52 and gastric cancer53 an immunosuppressive tumor microenvironment and the extent of intratumoral Foxp3+ expression correlates with disease progression and poor prognosis54, 55, 56. The gene discussed is FOXP3; the disease is Allergy.