Although perifosine low concentrations did not induce lung cancer cell death when used alone, it significantly potentiated paclitaxel-mediated apoptosis, as shown by the 2-fold increase in Annexin-V positive cells when exposed to paclitaxel 2 nM and perifosine 1 μM (Fig. 3a). The gene discussed is ANXA5; the disease is lung cancer.