In conclusion, we propose that, at least in laryngeal squamous cell carcinomas and basal-like breast carcinomas, the observed intracellular LOXL2 staining pattern corresponds to protein temporally retained in the ER that activates the IRE1-XBP1 and PERK branches of the UPR. The gene discussed is EIF2AK3; the disease is laryngeal squamous cell carcinoma.