CLOCK and neuroblastoma: Altman et al. reported that overexpression of MYC in U2OS cells and MYCN in neuroblastoma-derived cells correlates with increased expression of REV-ERBα, and they proposed that MYC activates REV-ERBα, which then represses BMAL1. Based on the well-established wiring of the transcriptional network of the circadian clock there is no doubt that accumulation of sufficient amounts of REV-ERBα will repress BMAL1, and it has been shown experimentally that overexpressed REV-ERBα disrupts the circadian clock in mouse liver4.