Then miR‐145‐5p and NRAS expression levels were evaluated in three melanoma cell lines including CHL‐1 (wild type), VMM917 (NRAS mutation), and SK‐mel‐28 (BRAF mutation), and normalized to normal human epidermal melanocytes (NHEMs), all the melanoma cell lines showed significantly lower levels of miR‐145‐5p with concurrent higher levels of NRAS (P < 0.01, Fig. 1D). This evidence concerns the gene BRAF and melanoma.