INS and Insulin resistance: It has been postulated that abnormalities in insulin action (both insulin resistance and hyperinsulinemia), contribute to important comorbidities including: glucose intolerance, type 2 diabetes mellitus (DM2), dyslipidemia, increased plasma triglycerides and decreased plasma high-density lipoprotein cholesterol (HDL-C), hypertension, and atherosclerosis (7, 8).