HFE hemochromatosis occurs as an autosomal recessive trait [11, 12] in 0.3–0.6% of whites of European descent [13–15] that is due to homozygosity for p.C282Y of the HFE gene (chromosome 6p21.3) [13]. HFE is linked to the major histocompatibility complex (MHC) [13]. This evidence concerns the gene HFE and hemochromatosis.