APC and Familial adenomatous polyposis: Most FAP cases are resulting from germ line mutations in APC. Mutations are located mainly at the 5′ end, but extend all over the length of the APC. Most of which are small deletions/insertions or point mutations, and most result in N-terminus of protein fragments failing the protein in binding and degradation of β-Catenin and consequently cannot suppress Wnt/ β-Catenin pathway (34, 120).