Axin2 likely plays a significant role in the regulation of the stability of β-Catenin in the Wnt pathway; it forms a complex of APC, β-Catenin, glycogen synthase kinase 3-beta (GSK3b), and conduction, which leads to the degradation of β-Catenin. This gene appears to act as a tumor suppressor, and somatic mutations have been seen in many different tumor types such as FAP tumors. This evidence concerns the gene AXIN2 and neoplasm.