TP53 and Familial adenomatous polyposis: This gene encodes a tumor suppressor protein, including transcriptional activation, oligomerization areas and DNA binding, The encoded protein responds to varying cellular stresses to control expression of target genes, therefore inducing DNA repair, senescence, apoptosis, cell cycle arrest, or alterations in metabolism. Mutations in TP53 are associated with a diversity of human syndrome, such as FAP. P53 expression was only slightly increased in adenomas, but more often expressed in carcinomas in FAP patients (Frequency: 35-55).