In a recent meta-analysis study, a link between MTHFR 677C>T and T2DM was established, showing that subjects with the T allele of the MTHFR 677C>T variant have significantly higher risk of having diabetes (OR 1.31, p = 0.032) than carriers of the C allele [30]. The gene discussed is MTHFR; the disease is type 2 diabetes mellitus.