Cardiopulmonary stress test revealed a reduction in maximum systolic blood pressure (P = 0.002), and increased maximum heart rate (P = 0.034), rate-pressure product (P < 0.0001), test duration (P < 0.0001), and VO2 max (P < 0.0001) with consequent significantly higher exercise tolerance, one of the most crucial target in the HF treatment, after CRP. This evidence concerns the gene CRP and hydrops fetalis.