Likewise, inappropriate activation of IL-1β and NALP3 is a common feature of a wide range of major human diseases, such as gout [19], type 2 diabetes [20], obesity-induced insulin resistance [21], Crohn's diseases [22], silicosis [23], psoriasis [10], cancer [4, 24], atherosclerosis [8], and Alzheimer's disease [25], known to affect millions of people worldwide. The gene discussed is NLRP3; the disease is cancer.