Also, Ocln knock-out mice showed calcification in the brain, testicular atrophy, loss of cytoplasmic granules in striated duct cells of the salivary gland, and thinning of the compact bone, but in Ocln knockout-mice, morphology of the TJs does not appeared to be affected and barrier function of epithelium is normal37 and cells originating from Ocln-deficient embryonic stem cells have well-developed networks of tight-junction strands38, suggesting that the functions of Ocln are more complicated than previously supposed. The gene discussed is OCLN; the disease is Testicular atrophy.