Human ABCB4 mutations result in progressive familial intrahepatic cholestasis type 3, intrahepatic cholestasis of pregnancy, low phospholipid-associated cholelithiasis, primary biliary cirrhosis, cholangiocarcinoma and hepatocellular carcinoma8, 9, 42, 43. Here, ABCB4 is linked to Intrahepatic cholestasis of pregnancy.