To investigate the effects of Wnt signalling on schistosomiasis-induced liver fibrosis, two lentiviral vectors loaded with Wnt3a (Lv-Wnt3a-EGFP) or DKK1 (Lv-DKK1-EGFP) were successfully established and injected via the tail vein into mice infected with S. japonicum for 6 weeks and into normal mice. This evidence concerns the gene DKK1 and schistosomiasis.