In both PK-EGFP and PK-pOASL cells, knockdown of RNase L resulted in increased luciferase activities (Fig. 4C), extracellular viral titers (Fig. 4D), and viral genomic copy numbers (Fig. 4E) compared to those in siNC-transfected cells after infection with rCSFV-Fluc or Shimen. The gene discussed is RNASEL; the disease is infection.