TEX101 was not a useful marker of unexplained infertility (AUC = 0.56, 95% CI 0.48–0.63, P > 0.05), but performed well in oligospermia (AUC = 0.88, 95% CI 0.84–0.92, P < 0.001) and azoospermia (AUC = 0.99, 95% CI 0.98–1.00, P < 0.001). Here, TEX101 is linked to Azoospermia.