Noteworthy, in one case (patient 31), although H1047R mutation quantification went down to 0% over the course of treatment (from 0.19 to 0%; Table 2) correlating with tumor markers CA15.3 and CEA variations and with the decrease in size of the pulmonary metastases and the axillary lymphadenopathy, the contrast-enhanced CT scan from the same period of time demonstrated that the lytic bone metastases increased in size (Fig. 1c). Here, CEACAM5 is linked to neoplasm.