Investigation of the genes (ACTN1, ACTN4, ADCY6, CTNNB1, DSP, EMD, ITGA2, ITGA5, ITGAV, ITGB1, ITGB3, ITGB5, JUP, PRKAA1, TPM1, TPM2, TPM4, and TCF7) clustered under the cardiomyopathy pathways revealed involvement of these genes in calcium binding pathways. This evidence concerns the gene TPM4 and cardiomyopathy.