Similarly, CREBBP (Mullighan et al. 2011), CRK (Sriram and Birge 2010), PTPN6 and PTPRU (Hoekstra et al. 2012) genes which might play a probable role in cancer revealed premature termination with loss of domains related to function as shown in Table 2. The gene discussed is PTPRU; the disease is cancer.