In another study on Swedish men, significant increase in fasting glucose and insulin were found over the 5-year follow-up among individuals homozygotes for the BclI allele of GRL gene whereas no significant associations were found with Tth111I or A/G polymorphism of GRL gene with T2DM (Rosmond and Holm 2008). This evidence concerns the gene INS and type 2 diabetes mellitus.