L-Asparaginase therapy has side effects such as anaphylaxis, coagulation abnormality, thrombosis, liver dysfunction, pancreatitis, hyperglycaemia and cerebral dysfunction, etc.These side effects are either due to the production of anti-asparaginase antibody in the body or l-glutaminase activity of l-asparaginase enzyme (Haskell et al. 1969; Mahajan et al. 2012). This evidence concerns the gene ASPG and Hyperglycemia.