In blood vascular system, l-Asparaginase hydrolyses l-Asn into l-Aspartic acid and ammonia building the leukemic cells barren of essential exogenous l-Asn, leading to protein synthesis inhibition followed by apoptosis (Lubkowski et al. 1994; Neuman and McCoy 1956; Mashburn and Wriston 1964), hence making this potent against ALL. Here, ASPG is linked to acute lymphoblastic leukemia.