TNF and tuberculosis: The TNF-α–only TEFF signature could almost completely distinguish between individuals with tuberculosis and those with remotely acquired LTBI, with an AUC of 0.99 revealed using either the raw data or after CV analysis (CV error rate, 0.7); comparison of these groups showed that a cutoff of >22.9% could distinguish between groups with a sensitivity of 100% (95% CI, 83.16%–100%) and a specificity of 95% (95% CI, 75.13%–99.87%; Figure 1C).