Jia et al reported that endothelial overexpression of human CYP2J2 protected against experimental cerebral ischemia in male mice, and that the levels of 11,12- and 14,15-EETs were increased in culture medium containing aortic endothelial cells isolated from the same transgenic mice (Tie2-CYP2J2 Tr) [8]. Here, CYP2J2 is linked to brain ischemia.