Evidence from studies of other malignancies like colorectal cancer has shown that proinflammatory cytokines such as TNFα and IL-1β increase tumor cell adhesion to endothelial cells in vitro and in vivo by upregulating the expression of cell adhesion molecules.[21–23] Most posited mechanisms are about how infective complications affect oncological outcomes. The gene discussed is IL1B; the disease is colorectal cancer.